Hotel Artemis is a cutting-edge but highly secretive healthcare facility catering exclusively to wealthy underworld clientele. Manager Jean Thomas runs the “hotel” with an iron fist. Its clients are murderers, gangsters and criminals of the deepest dye, and it offers exclusive services such as a brand-new, 3D-printed liver– for an equally exclusive price, of course. But after the emergency hospitalization of infamous kingpin Orian Franklin, what was a safe haven is transformed into a deadly, explosive minefield.